Global pattern and prevention strategies of Macrolide-resistant Mycoplasma infections: JAMA

Researchers from Japan conducted a study on the Global trends of Macrolide-resistant Mycoplasma Pneumonia (MRMP) infections and a proposed few prevention strategies for MRMP infections. The findings were published in the journal, JAMA Network Open, 2022.  

Mycoplasma Pneumonia is the most common cause of pediatric community-acquired pneumonia. Recent evidence shows the increasing trends of refractory M. pneumonia infections. The proportion of infections caused by macrolide-resistant Mycoplasma pneumoniae (MRMP) has changed and varies by geographical region. So, researchers conducted a systematic review and meta-analysis to analyze the global patterns, and understand the temporal trends, regional variations, and variant types. 

Observational studies were collected from databases like PubMed, Cochrane Library, and Embase using a search strategy from inception till September 2021. Two authors independently screened the proportion of MRMP infections. Two reviewers independently extracted data and duplicated it. Any instance of M pneumoniae infection that tested positive for any variant linked to macrolide resistance and discovered using respiratory samples was considered to have MRMP infection. The extracted data were subjected to PRISMA guidelines and Random-effects meta-analyses were used to estimate the proportion of MRMP infections. The main outcome of measurement was estimating the global patterns and investigating the temporal trends, and variant types of MRMP infection with regional differences.