Higher Caffeine Intake Linked to Lower Risk of Liver Fibrosis, finds study

Key Findings

• In the prediabetes group, the mean age was 53 ± 0.4 years, while among the T2DM group the mean age was 62 ± 0.3 years.

• Prevalence of liver fibrosis was notably higher in T2DM (5.9%) than in individuals with prediabetes (3.2%) and those who are free from diabetes (2.5%) (p< 0.001).

In comparison to persons with daily caffeine consumption <78 mg, those with ≥78 mg of caffeine daily had a significantly reduced risk of liver fibrosis:

• Diabetes-free group: odds ratio (OR) = 0.698 [95% CI: 0.577–0.846]

• Prediabetes group: OR = 0.553 [95% CI: 0.397–0.769]

• T2DM group: OR = 0.720 [95% CI: 0.556–0.933]

Researchers found the prevalence of liver fibrosis in people of various glucose metabolism statuses and points to the usefulness of caffeine use in lowering risk of fibrosis. Patients with prediabetes could be recommended to undergo screening for fibrosis. Caffeine consumption could be a simple and non-pharmacological method for reducing the risk of fibrosis, although there is a necessity for further study to investigate underlying mechanisms and long-term effects.

Reference:

Han, J., Liu, C., Yang, H., Dong, Z., Li, X., Gao, R., Li, J., Zhang, Q., Ming, W.-K., Li, Z., Li, J., & Qi, X. (2025). Caffeine intake associated with a lower risk of liver fibrosis in different glucose status. Journal of Advanced Research. https://doi.org/10.1016/j.jare.2025.02.004