Ketamine Emerges as Noninferior Alternative to Morphine for Out-of-Hospital Traumatic Pain
In the midst of the opioid crisis, a recent study, the Intravenous Subdissociative-Dose Ketamine Versus Morphine for Prehospital Analgesia (KETAMORPH), has explored the viability of ketamine as an alternative to opioids for managing out-of-hospital traumatic pain. With pain being a prevalent symptom among patients outside healthcare settings, the research aimed to assess the noninferiority of intravenous ketamine compared with intravenous morphine sulfate in providing pain relief for adults facing traumatic pain.
This study was published in the journal of JAMA Network Open by Clement Le and colleagues. The KETAMORPH study, a multicenter, single-blind, noninferiority randomized clinical trial, enrolled 251 adult patients with out-of-hospital trauma and a verbal pain score equal to or greater than 5. These patients were randomly assigned to receive either ketamine (n=128) or morphine (n=123). The primary outcome measured the mean change in verbal rating scale pain scores from before administration to 30 minutes later, with a noninferiority margin of 1.3.
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