Obicetrapib excels as lipid lowering agent in Phase 3 trials
Obicetrapib, a highly selective oral CETP inhibitor, has shown significant promise in a Phase III trial by dramatically reducing LDL cholesterol levels in high-risk individuals who had an inadequate response to existing lipid-lowering therapies, all without noticeable side effects. These findings support its potential as an effective treatment for patients already on maximal lipid-lowering therapy. Additionally, a cardiovascular outcomes trial is currently underway to evaluate its long-term impact in adults with a history of atherosclerotic cardiovascular disease and persistently high LDL cholesterol.
Obicetrapib is a highly selective cholesteryl ester transfer protein inhibitor that reduces low-density lipoprotein (LDL) cholesterol levels. The efficacy and safety of obicetrapib have not been fully characterized among patients at high risk for cardiovascular events.
They conducted a multinational, randomized, placebo-controlled trial involving patients with heterozygous familial hypercholesterolemia or a history of atherosclerotic cardiovascular disease who were receiving maximum tolerated doses of lipid-lowering therapy. Patients with an LDL cholesterol level of 100 mg per deciliter or higher or a non–high-density lipoprotein (HDL) cholesterol level of 130 mg per deciliter or higher, as well as those with an LDL cholesterol level of 55 to 100 mg per deciliter or a non-HDL cholesterol level of 85 to 130 mg per deciliter and at least one additional cardiovascular risk factor, were eligible for inclusion.
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