Oral antibiotics as effective as IV therapy in bone and joint infections, finds study
Researchers have found in a new study that Oral antibiotics as effective as intravenous therapy in bone and joint infections, finds study.
A study by UK researchers published recently in Clinical Infectious Diseases indicates that findings of the Oral Versus Intravenous Antibiotics (OVIVA) trial can be implemented into clinical practice.
The Oral Versus Intravenous Antibiotics (OVIVA) Trial, the first prospective study of its kind, had demonstrated that oral therapy, when used during the initial 6 weeks in the treatment in bone and joint infection (BJI), is non-inferior to intravenous therapy in patients were randomized to receive 6 weeks of either IV or oral (PO) antibiotics for a broad range of BJIs.
The results of the trial were initially presented in 2017 and published in 2019, but to date, there have been no reports describing their reproducibility in real-world settings.
To determine whether the OVIVA findings can be replicated, researchers under Tariq Azamgarhi from Pharmacy Department, Royal National Orthopaedic Hospital NHS Trust, UK, in collaboration with the Royal National Orthopaedic Hospital, which implemented changes in practice in 2017 based on the results, looked at all patients diagnosed as having BSI at the hospital in the 12 months pre- and post-implementation. Outcomes included treatment failure, adverse drug reactions (ADRs), ADR-related hospital readmission, hospital length of stay (LOS), and treatment costs. Patient follow-up was conducted by an outpatient parenteral antibiotic therapy (OPAT) service.
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