Short-course antibiotic therapy okay for Pseudomonas bloodstream infections in febrile neutropenia
Antibiotic resistance, gut microbiome disturbances and adverse events have stimulated interest in revisiting standard antibiotic treatment durations. Studies suggest shorter courses may be as effective as longer ones for community-acquired pneumonia, ventilator-associated pneumonia, urinary tract infections, cellulitis, and intra-abdominal infections.
A study published in Clinical Infectious Diseases by Feng et al. and colleagues has concluded that short-course therapy is non-inferior to prolonged-course treatment pertaining to clinical outcomes.
Based on previous studies, short-course antibiotic therapy was effective in Pseudomonas aeruginosa (PA) bloodstream infections (BSI) in immunocompetent patients.
The cohort study involved patients with onco-hematology conditions at two hematology centres in China. To eliminate confounding factors, inverse probability of treatment weighting was utilized. A multivariate regression model was then employed to determine the impact of short-course antibiotic therapy on clinical outcomes.
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.