Single dose of omalizumab before pollen season beneficial in seasonal allergic rhinitis: Study
A dose of omalizumab administered before pollen season improved symptom control and quality of life compared with standard medication among patients with seasonal allergic rhinitis, according to a study in Clinical and Translational Allergy.
To date, no study has evaluated the efficacy of preseasonal omalizumab therapy with a cost-effective dose and at an appropriate time point compared with standard medication in seasonal allergic rhinitis (SAR) patients.
This was a prospective randomized controlled open-label single-centre trial. 32 SAR patients were randomized to receive a single injection of omalizumab 300-mg approximately two weeks before the start of the pollen period (PP) or medication therapy. All patients completed daily questionnaires; recording symptoms, medication use and quality of life (QoL) throughout the observation period. The primary efficacy parameter was the mean daily Combined Symptom and Medication Score (CSMS).
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