Thrombopoietin and steroid combo frontline treatment for ITP patients: Study

In the prospective, multicenter, randomized, controlled clinical trial, the enrolled patients were randomly assigned to receive DXM plus rhTPO or DXM monotherapy. If the response was not achieved by day 10 in both arms, another 4‐day course of DXM was repeated. The full analysis set included 100 patients in the HD‐DXM plus rhTPO arm and 96 patients in the HD‐DXM monotherapy arm. 

Key findings of the study include:

"The combination of HD‐DXM with rhTPO significantly improved the initial response and yielded favorable SR in newly diagnosed ITP patients, thus could be further validated as a frontline treatment for ITP. 

The study, "High‐dose dexamethasone plus recombinant human thrombopoietin versus high‐dose dexamethasone alone as frontline treatment for newly diagnosed adult primary immune thrombocytopenia:a prospective, multicenter, randomized trial," is published in the American Journal of Hematology.

DOI: https://onlinelibrary.wiley.com/doi/abs/10.1002/ajh.25989