WHO guidance backs Use of Corticosteroids in Severe COVID-19 infection
The World Health Organization recommends systemic corticosteroids to treat patients with severe and critical COVID-19.WHO has updated its guidance for healthcare professionals and decision-makers on the use of corticosteroids in COVID-19 patients, according to a WHO press release.
The study, conducted by the World Health Organization (WHO) Rapid Evidence Appraisal for COVID-19 Therapies (REACT) investigators, analyzed data from 1,703 patients enrolled in the trials.
In a tremendous demonstration of global collaboration, clinician-scientists have pooled data from 121 hospitals in eight countries to find that inexpensive, widely available steroids improve the odds that very sick COVID-19 patients will survive the illness.
The findings were made through the "Randomized Embedded Multifactorial Adaptive Platform-Community Acquired Pneumonia" (REMAP-CAP) trial and are reported today in JAMA as part of a four-article package.
It is relatively rare in medicine that you find drugs where the evidence of their effectiveness in saving lives is so consistent," said lead author Derek Angus, M.D., M.P.H., professor and chair of the Department of Critical Care Medicine at the University of Pittsburgh and chief health care innovation officer at UPMC. "This is, in many respects, the single clearest answer we've had so far on how to manage terribly ill COVID-19 patients. People on ventilators or oxygen and under intensive care should definitely be given corticosteroids."