Thromboprophylaxis with aspirin non-inferior to heparin after fracture: NEJM
USA: Thromboprophylaxis with aspirin is non-inferior to low-molecular-weight heparin in patients with extremity fractures that had been treated operatively or with any pelvic or acetabular fracture with regards to prevention of death, according to PREVENT CLOT trial.
In the study published in the New England Journal of Medicine, thromboprophylaxis with aspirin was associated with low incidences of pulmonary embolism, deep-vein thrombosis, and low 90-day mortality. Also, the authors did not find any evidence of additional safety risks associated with aspirin thromboprophylaxis in the trial population.
In patients with fractures, clinical guidelines recommend low-molecular-weight heparin for thromboprophylaxis, but there is a lack of trials of its effectiveness compared with aspirin. Considering this, the researchers conducted a pragmatic, multicenter, randomized, noninferiority trial enrolling patients 18 years and above who had a fracture of an extremity (anywhere from shoulder to the wrist or hip to midfoot) that had been treated operatively or who had any acetabular or pelvic fracture.
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