Unique probiotic may prevent neurodegeneration and restore lipid balance in amyotrophic lateral sclerosis

By restoring lipid homeostasis and energy balance through mitochondrial-oxidation, dietary supplementation of unique probiotic containing L. rhamnosus HA-114 prevents neurodegeneration and disturbed lipid metabolism in amyotrophic lateral sclerosis.

The study has been published in Communications Biology.

It is thought that the human microbiome affects health. Neurological disorders including Alzheimer's disease, amyotrophic lateral sclerosis, and Huntington's disease may be associated with microbiome dysbiosis. In this work, Audrey Labarre and colleagues describe how a probiotic bacterial strain can stop the hallmarks of neurodegeneration. Additionally demonstrated to be neuroprotective in C. elegans models of Huntington's disease and amyotrophic lateral sclerosis is lacticaseibacillus rhamnosus HA-114.

The bacterium Lacticaseibacillus rhamnosus HA-114 is present in the probiotic. 13 distinct bacterial strains and three strain combinations were examined by the researchers. HA-114 stood out among the other models. Animal models for amyotrophic lateral sclerosis (ALS) or Huntington's illness experienced less motor abnormalities according to the probiotic's effect. The group discovered two genes involved in mitochondrial -oxidation and fatty acid metabolism that looked to be crucial in this neuroprotective process.