Orange juice may reverse obesity and reduce risk of heart disease and diabetes
Research published in the Journal of Lipid Research has outlined that flavonoid nobiletin present in oranges may reduce the risk of heart disease and diabetes.;
Obesity, dyslipidemia, and insulin resistance, the increasingly common metabolic syndrome, are risk factors for CVD and type 2 diabetes that warrants novel therapeutic interventions.
The equivalent of just two and a half glasses of orange juice a day could reverse obesity and reduce the risk of heart disease and diabetes. Researchers at Western University are studying a molecule found in sweet oranges and tangerines called nobiletin, which they have shown to drastically reduce obesity and reverse its negative side-effects.
New research published in the Journal of Lipid Research demonstrates that mice fed a high-fat, high-cholesterol diet that was also given nobiletin were noticeably leaner and had reduced levels of insulin resistance and blood fats compared to mice that were fed a high-fat, high-cholesterol diet alone.
"We went on to show that we can also intervene with nobiletin," said Murray Huff, PhD, a professor at Western's Schulich School of Medicine & Dentistry who has been studying nobiletin's effects for over a decade. "We've shown that in mice that already have all the negative symptoms of obesity, we can use nobelitin to reverse those symptoms, and even start to regress plaque build-up in the arteries, known as atherosclerosis."
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