24-h versus PET samples: Which is better for quantification of peritoneal protein loss?
Portugal: Peritoneal protein loss (PPL) quantification may be expressed in accordance with a timely collection (24-h measurement or 4-h PET assessment) and as a concentration.
A recent study in the Karger journal Blood Purification has found that measurements of a 24-h sample might be closer to the clinical status and prognosis of the patient, indicating opportunities for therapy intervention. Further, the researchers found that the quantification of PET protein loss should be regarded as a marker of peritoneal membrane intrinsic permeability.
Guedes A. Malho and colleagues from Portugal aimed to compare the quantification methods of 24-h and 4-h collections. The study included 81 prevalent peritoneal dialysis patients. Registration of demographics and clinical and bioelectrical impedance features was done. Measurement of PPL (4-h PET and 24-h results) was done and peritoneal protein clearance was calculated. A linear regression model was performed.
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