What this really means is that the TyG index may serve as a practical, accessible biomarker for identifying individuals at higher risk of CKD before more overt signs of kidney damage appear. The investigators found that even over relatively short follow-up periods, elevated TyG values predicted earlier onset of reduced kidney function, supporting its potential use in early risk stratification. Their discussion emphasizes that insulin resistance—of which the TyG index is a surrogate—may drive kidney damage via endothelial dysfunction, oxidative stress, inflammation and glomerular hyperfiltration, thereby providing a plausible mechanistic link between elevated TyG and declining renal health. The authors propose that in clinical practice, routine measurement of the TyG index could help prompt closer renal monitoring, lifestyle or pharmacologic interventions aimed at reducing metabolic stress.
Of course, the study has limitations: it is observational in design, and although multivariable adjustments were made, residual confounding cannot be excluded. Additionally, the cohort was drawn from a specific population and the threshold values of TyG for risk stratification are not yet standardized. Nevertheless, the findings highlight the potential of the TyG index as a simple, cost-effective tool for early kidney disease prevention—especially in patients with elevated triglycerides or impaired glucose metabolism. It opens the door to future research on whether interventions to lower the TyG index can translate into slower kidney disease progression or reduced incidence of CKD.
Keywords: TyG index, chronic kidney disease, risk stratification, insulin resistance, fasting triglyceride–glucose.
Reference: Zhang Y., et al. Elevated TyG Index and Risk of Chronic Kidney Disease in Adults. Renal Failure. 2025; 47(1): 2572356.
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