Albuminuria emerges as key predictor of chronic kidney disease progression: Landmark cohort study unveils critical findings
USA: In a groundbreaking development, a comprehensive cohort study has unearthed a pivotal association between albuminuria and chronic kidney disease (CKD) progression. This seminal research, conducted by a multidisciplinary team of experts, represents a significant leap forward in understanding the trajectory of CKD and holds profound implications for patient care and management strategies.
The study, published in the Annals of Internal Medicine, revealed that patients with CKD and normoalbuminuria (<30 mg/g) had an excess risk for CKD progression, which increased linearly with higher albuminuria levels.
Chronic kidney disease, a global public health concern affecting millions worldwide, is characterized by a gradual decline in renal function over time. While albuminuria, the presence of albumin in urine, has long been recognized as a hallmark of kidney damage, its precise role in disease progression has remained a subject of intense scrutiny.
Albuminuria is a major risk factor for CKD progression, especially when categorized as moderate (30 to 300 mg/g) or severe (>300 mg/g). However, data is limited on the prognostic value of albuminuria within the normoalbuminuric range (<30 mg/g) in patients with CKD. Ashish Verma, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, and colleagues aimed to estimate the increase in the cumulative incidence of CKD progression with greater baseline albuminuria levels among CKD patients who had normoalbuminuria (<30 mg/g).
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