Belimumab add on improves renal response in lupus nephritis patients: NEJM
USA: The addition of belimumab to standard therapy improved renal outcomes in patients with lupus nephritis, according to a recent study in the New England Journal of Medicine.
Brad H. Rovin, Ohio State University, and colleagues aimed to determine the efficacy and safety of intravenous belimumab as compared with placebo, when added to standard therapy (mycophenolate mofetil or cyclophosphamide–azathioprine), in patients with active lupus nephritis.
For the purpose, the researchers conducted a phase 3, multinational, multicenter, randomized, double-blind, placebo-controlled, 104-week trial at 107 sites in 21 countries. 448 patients were assigned to receive intravenous belimumab (at a dose of 10 mg per kilogram of body weight) -- belimumab group (n=224) or matching placebo (n=224), in addition to standard therapy.
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