Cefepime-taniborbactam superior to meropenem in treating complicated UTIs and acute pyelonephritis: NEJM
Written By : Aditi
Medically Reviewed By : Dr. Kamal Kant Kohli
Published On 2024-02-20 01:45 GMT | Update On 2024-02-20 01:45 GMT
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Carbapenem-resistant Enterobacterales species and multidrug-resistant Pseudomonas aeruginosa pose significant global health threats. Cefepime–taniborbactam is an investigational β-lactam and β-lactamase inhibitor combination with activity against these organisms.
A study published in The New England Journal of Medicine (NEJM) concluded that Cefepime-taniborbactam was more effective than meropenem in treating complicated urinary tract infections involving acute pyelonephritis and had a safety profile comparable to meropenem.
In this phase 3 trial, researchers assigned hospitalized adults with complicated UTIs to receive either cefepime-taniborbactam or meropenem for seven days, with the possibility of extending treatment for an additional seven days if bacteremia was present. The composite success rate on days 19-23 in the microbiologic intention-to-treat population determined the primary outcome. After confirming non-inferiority, a prespecified superiority analysis was conducted.
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