Cirrhosis patients undergoing contrast-enhanced CT not at higher risk of incident AKI compared to controls, finds study

Written By : Aditi

Medically Reviewed By : Dr. Kamal Kant Kohli

Published On 2024-03-14 20:30 GMT | Update On 2024-03-14 20:30 GMT

Intravenous iodinated contrast media (ICM) in cirrhosis patients may cause nephrotoxicity, but research is limited and based on small, heterogeneous studies.

According to a recent study published in the Journal of Hepatology, researchers concluded that The risk of acute kidney injury (AKI) following contrast-enhanced computed tomography (CECT) in patients with cirrhosis is relatively low and comparable to that of both the general population and cirrhotic individuals who have not been exposed to intravenous iodinated contrast media (ICM). AKI incidents in these cases are typically mild and resolve quickly without causing tubular kidney damage. It appears that only patients with active infections are at a greater risk for AKI.

This study evaluated AKI incidence and risk factors in cirrhosis patients who undergo CECT. A prospective, multicenter study was conducted, including 444 inpatients, 148 with cirrhosis (cohort 1), 163 without cirrhosis (cohort 3) undergoing CECT and 133 with cirrhosis (cohort 2) who did not receive ICM. Kidney function parameters were measured at T0, 48-72 h (T1), 5 and 7 days after CECT/enrollment. U-NGAL or Urinary neutrophil gelatinase-associated lipocalin was measured as an early biomarker of tubular damage. in 50 consecutive patients from cohort 1 and 50 from cohort 2

Key findings from the study are:

• The incidence of AKI was not significantly increased in cirrhosis patients undergoing CECT. The recorded percentages for cohorts 1,2 and 3 were 4.8%, 1.5%, and 2.5%, respectively.

• Most cases of AKI were mild and temporary.

• Concomitant infections was the only predictive factor of contrast-induced AKI, with an odds ratio of 22.18

• No significant changes in the U-NGAL between T0 and T1 were detected,

This research study emphasized that the risk of acute kidney injury (AKI) in individuals with cirrhosis after receiving intravenous iodinated contrast media was relatively low and not significantly different from that of the general non-cirrhotic population. The majority of cases involved mild and rapidly resolving episodes of renal dysfunction, and administration of iodinated contrast media was not linked to subclinical tubular kidney injury. Conversely, active infections were the sole independent predictor of contrast-induced AKI.

Reference:

Campion, D. et al. A prospective, multicenter, three-cohort study evaluating contrast-induced acute kidney injury (CI-AKI) in patients with cirrhosis. Journal of Hepatology.

Article Source : Journal of Hepatology

Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.

NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.

Aditi

Dr. Aditi Yadav is a BDS, MDS in Periodontics and Implantology. She has a clinical experience of 5 years as a laser dental surgeon. She also has a Diploma in clinical research and pharmacovigilance and is a Certified data scientist. She is currently working as a content developer in e-health services. Dr. Yadav has a keen interest in Medical Journalism and is actively involved in Medical Research writing.

Comments Policy

Our comments section is governed by our Comments Policy . By posting comments at Medical Dialogues you automatically agree with our Comments Policy , Terms And Conditions and Privacy Policy .

Cirrhosis patients undergoing contrast-enhanced CT not at higher risk of incident AKI compared to controls, finds study

Similar News

FDA Approves Bumetanide Nasal Spray for Edema in Heart, Liver, and Kidney Disease

Lower Irisin Levels Linked to Diabetic Nephropathy Progression in T2DM: Study

Acute Kidney Injury Before or During ECMO Linked to Higher Mortality, Study Finds

Vancomycin Linked to Higher AKI Risk in ICU Patients: Study

Even Mild Aldosterone Increase Linked to Hypertension and Kidney Disease Risk: Study

Prioperative Dexmedetomidine Fails to Prevent AKI After Partial Nephrectomy, suggests study

Rheumatoid Arthritis Patients Face Higher Risk of Kidney Stones: Study

Developing novel drug for acute MI, acute kidney injury, and subsequent chronic organ failure: Study