Colistin has high nephrotoxicity risk, use as last resort antibiotic: Study
USA: Colistin should be used as a last resort treatment and when possible safer alternatives should be considered, suggests a recent review in the journal Open Forum Infectious Diseases. The review found a colistin-associated nephrotoxicity rate to be of 36.2% and increase in nephrotoxicity by 140% compared to β-lactam-based regimens.
The use of polymyxin antibiotics, including colistin is generally associated with nephrotoxicity. Previous meta-analyses that characterized colistin-associated nephrotoxicity risk compared to other antibiotics included observational studies with high risk of heterogeneity and confounding. Samah Alshehri, University of Arizona, Tucson, Arizona, USA, and colleagues conducted the systematic review and meta-analysis of exclusively randomized controlled trials (RCTs) for evaluating nephrotoxicity incidence associated with colistin versus minimally nephrotoxic antibiotics.
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