Curcumin may Mitigate BEP-Induced Kidney Toxicity, reveals study
Researchers have found in a new study that curcumin offers renal protection against BEP chemotherapy-induced toxicity by reducing oxidative stress, inflammation, and cell death, suggesting its potential as a therapeutic option for managing BEP-related kidney complications.
Bleomycin, etoposide, and platinum (BEP) are among the most commonly used and effective anticancer medications in oncology clinics.
The study’s objective was to examine the efficacy of curcumin and curcumin-cyclodextrin (nanocurcumin) as protective agents against BEP nephrotoxicity. Renal toxicity was evaluated through various parameters, such as histopathology and serum urea and creatinine levels. In addition, the levels of Nitric Oxide (NO) and total antioxidant capacity (TAC) and the expression of the Tumor Necrosis Factor-alpha (TNF-α) and caspase 3 genes were investigated.
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