Cytoreductive Nephrectomy beneficial in metastatic renal cell carcinoma: Study

Most metastatic renal cell carcinoma patients are symptomatic, and they should be aware that cytoreductive nephrectomy has a positive impact on symptomatic status, suggests a recent report published in European Urology.
Renal cancer is one of the most frequently diagnosed solid malignancies, and in almost one out of five patients, the disease is metastatic at presentation. The 2019 update of the European Association of Urology guidelines on renal cell carcinoma, advises against immediate cytoreductive nephrectomy (CN) in favor of systemic therapy for patients with metastatic renal cell carcinoma (mRCC) and asymptomatic presentation. The role of cytoreductive nephrectomy (CN) patients with metastatic renal cell carcinoma (mRCC) are unclear to date.
With this in mind, Alessandro Larcher et al undertook a study to define the proportion of symptomatic mRCC, to investigate the impact of CN on symptomatic improvement and perioperative morbidity, and to elucidate the trade-off between such benefit and harm.
An observational study of 317 mRCC patients treated with CN was performed. Symptomatic mRCC was defined as the presence of any sign or symptom causally related to the disease. Sign or symptom resolution and improvement were defined as the absence of all the signs and symptoms recorded at baseline, and the absence of at least one sign or symptom recorded at baseline, respectively.
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