Denosumab Linked to High Incidence of Severe Hypocalcemia in Female Dialysis Patients 65 and Above: JAMA
Written By : Aditi
Medically Reviewed By : Dr. Kamal Kant Kohli
Published On 2024-04-26 16:30 GMT | Update On 2024-04-27 06:15 GMT
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Osteoporosis, common in postmenopausal women, involves reduced bone density, fragile bones, and a higher fracture risk. Patients with advanced chronic kidney disease (CKD) have an elevated fracture risk. Dialysis-dependent older patients face a high risk of low bone mass due to primary osteoporosis, CKD–mineral and bone disorder (CKD-MBD), or both.
According to an Original Investigation published in JAMA, the use of Denosumab in elderly, female dialysis-dependent patients resulted in a statistically and clinically significant higher risk of severe hypocalcemia when compared to oral bisphosphonates.
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