Depression and low-grade inflammation may increase all-cause mortality in peritoneal dialysis patients
Depression and low-grade inflammation may increase all-cause mortality in peritoneal dialysis patients suggests a new study published in the BMC Nephrology.
The relationship between depression and systemic inflammation as risk factors for mortality is not well understood and requires further investigation.
Patients undergoing continuous ambulatory peritoneal dialysis (CAPD) between July 01, 2015 to December 31, 2019, were analyzed and followed up until December 31, 2020. According to their status of depression (PHQ-9 score ≥ 5) and low-grade inflammation (hs-CRP level ≥ 3 mg/L), patients were divided into four groups (G1, without depression, nor inflammation; G2, with depression, without inflammation; G3, with inflammation, without depression; G4, with both depression and inflammation). We performed Kaplan–Meier and multivariable Cox proportional analyses of mortality for the combined influence of depression and systemic inflammation in this cohort.
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