Fluctuating BMI linked to poor prognosis in Chronic Kidney Disease: Study
South Korean researchers found that people who had chronic kidney disease (CKD) with recent fluctuating body mass index showed higher risk of cardiovascular disease or death, without the influence of their current body mass index (BMI). They published the findings online in the Journal of American Society of Nephrology, August 2021 Issue.
In this retrospective study the authors looked into the relationship of BMI variability with risks of all-cause mortality, acute myocardial infarction, stroke, and the need for Kidney Replacement Therapy (KRT). 84,636 individuals with predialysis CKD in South Korea were included.
Variability in BMI or metabolic parameters until baseline measurement was the study exposure, which was computed as variance independent of the mean and divided into quartiles (with Q4 the highest quartile and Q1 the lowest).
o The study brought out that higher BMI variability was linked to increased risk of all-cause mortality, KRT, myocardial infarction, and stroke.
o Over the span of exposure assessment period the subgroups provided similar results regardless of the positive or negative trend in BMI.
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