Glomerular diseases linked to higher risk of cardiovascular conditions
Washington - Adults with glomerular diseases--which affect the kidney's filtering units where blood is cleaned--face a high risk of developing heart problems, according to a study that will be presented online during ASN Kidney Week 2020 Reimagined October 19-October 25.
Cardiovascular disease is a leading cause of morbidity and mortality in adults with reduced kidney function. To define the cardiovascular disease risk of patients with glomerular diseases--which include focal segmental glomerulosclerosis, membranous nephropathy, IgA nephropathy, and minimal change disease--investigators analyzed 2000-2012 information from a centralized kidney pathology registry in British Columbia, Canada.
Among 1,912 patients followed for a median of 6.8 years, there were 338 cardiovascular events, and the 10-year risk was 16.0% (7.7% for IgA nephropathy, 13.2% for minimal change disease, 19.4% for membranous nephropathy, and 27.0% for focal segmental glomerulosclerosis). Results showed cardiovascular event rates were high both prior to and after end stage kidney failure.
The risk of cardiovascular disease was 2.5-times higher in individuals with glomerular diseases compared with adults in the general population.
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