High glucose-to-lymphocyte ratio associated with poor prognosis in patients with sepsis-associated AKI

• Mortality Rates: Mortality rates, at various time points, increased incrementally with higher GLR levels. For instance, at 28 days, mortality was 11.64%, 22.00%, and 33.86% in GLR1, GLR2, and GLR3 groups, respectively.

• Association with Mortality: The GLR demonstrated a direct association with mortality, as higher GLR levels were significantly linked to increased mortality rates within 28 days.

• Predictive Value: The area under the ROC curve (AUC) for GLR in predicting 28-day mortality was 0.674, indicating moderate predictive ability. When combined with acute physiology score III (APS III) and sequential organ failure assessment (SOFA) score, the predictive performance improved substantially, with an AUC of 0.806.

The findings highlight the importance of assessing GLR alongside other established scores (APS III, SOFA) for a more accurate prediction of mortality risk in SA-AKI patients. This extensive investigation provides clinicians with a novel insight into utilizing GLR as a potential prognostic indicator in the assessment and management of SA-AKI patients, potentially aiding in tailored interventions and improved patient outcomes.

Reference:

Zhang, L., Liu, F., Li, Q., Li, Y., Shao, Q., Tao, W., Hu, P., Qian, K., & Lu, Y. (2023). Association between blood glucose-to-lymphocyte ratio and prognosis of patients with sepsis-associated acute kidney injury. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue, 35(12). https://doi.org/10.3760/cma.j.cn121430-20230901-00725