Hospitalized Sepsis patients have high risk for acute kidney injury: BMC

The key findings of this study were;

1. 163 (25.7%) and 324 (51.5%) of the 634 sepsis patients experienced hyperuricemia and AKI, respectively.

2. With statistically significant differences, the incidence of AKI was 76.7% and 42.3%, respectively, in the groups with and without hyperuricemia.

3. Hyperuricemia was found to be an independent risk factor for AKI in patients with sepsis after correcting for gender, comorbidities (coronary artery disease), organ failure assessment (SOFA) score on the day of admission, baseline renal function, serum lactate, calcitonin, and mean arterial pressure.

4. The incidence of AKI rose by 31.7% for every 1 mg/dL rise in blood uric acid in sepsis patients.

ICU patients with sepsis frequently develop AKI, and hyperuricemia is a unique risk factor for AKI in these patients. AKI in sepsis patients may be prevented by treating hyperuricemia, which may contribute to the pathophysiology of sepsis-related AKI.

Reference:

Jiang, Y.-X., Gong, C.-L., Tang, Y., Yi, Y., Liu, F.-G., Zhou, J.-W., Shi, Y.-L., Zhou, H.-W., & Xie, K.-Q. (2023). Association between hyperuricemia and acute kidney injury in critically ill patients with sepsis. In BMC Nephrology (Vol. 24, Issue 1). Springer Science and Business Media LLC. https://doi.org/10.1186/s12882-023-03129-x