Hyperkalemia due to RAASi is best managed by stopping the drugs
RAAS Inhibitor Discontinuation Lowers Risk of Recurrent Hyperkalemia Due to the Drugs, reveals a new Study;
Written By : MD Bureau
Medically Reviewed By : Dr. Kamal Kant Kohli
Published On 2021-07-07 03:30 GMT | Update On 2021-07-07 04:28 GMT
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Renin-Angiotensin-Aldosterone System Inhibitors (RAASi) may precipitate hyperkalemia which is best managed by discontinuing the drugs, according to a study published in the Clinical Journal of American Society of Nephrology.
RAASi are commonly prescribed in patients with Chronic Kidney Disease and a common complication of these drugs is hyperkalemia. Hyperkalemia is the increase of serum potassium levels. These drugs block the interaction of aldosterone with its receptors and reduce renal potassium excretion. The management of RAASi–related hyperkalemia to reduce the risk of recurrence is not known. With this background, a group of investigators from the University of Ottawa carried out a retrospective cohort among the Canadian population to examine the risk of hyperkalemia recurrence on the basis of outpatient pharmacologic changes following an episode of RAASi-related hyperkalemia.
49,571 patients who developed hyperkalemia while on RAASi therapy, with a median age of 79 years, were included in the study. The following groups were observed: no intervention, RAASi discontinuation, RAASi dose decrease, new diuretic, diuretic dose increase, or sodium polystyrene sulfonate within 30 days. The primary outcome was hyperkalemia recurrence, with secondary outcomes of cardiovascular events and all-cause mortality within 1 year.
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