Low levels of Vitamin D among Kidney stone disease patients linked to higher all-cause mortality
There is growing evidence that high levels of cholecalciferol or 25-hydroxyvitamin D may lead to increased excretion of calcium in the urine and an increased risk of kidney stones.
A recent study published in Frontiers in Endocrinology has concluded that patients with kidney stone disease (KSD)having insufficient serum 25(OH)D concentrations are at a higher risk of all-cause mortality.
This prospective cohort study included 2,916 National Health and Nutrition Examination Survey (NHANES) participants. All causes of death and cause-specific mortality were identified using The National Death Index (NDI). Multivariate Cox regression models calculated Hazard ratios and 95% confidence intervals.
This study aimed to determine the relationship between serum 25(OH)D levels and all-cause mortality in patients with kidney stone disease, as the effects of a deficiency in 25-hydroxyvitamin D on these patients are not well understood.
Key results of this study are:
- During the 18,859 person-years of follow-up, 375 fatalities occurred.
- Eighty-three deaths were from cardiovascular disease (CVD) and 79 from cancer.
- At baseline, individuals with higher blood 25(OH)D concentrations had lower glucose, glycohemoglobin, CRP, and insulin levels and higher HDL cholesterol levels.
- When compared to the group with the lowest 25(OH)D concentrations, those with serum 25(OH)D concentrations ≥75 nmol/L had hazard ratios (HRs) and 95% confidence intervals (CIs) of 0.48 for all-cause mortality.
- The association between serum 25(OH)D concentrations and all-cause mortality in KSD patients was non-linear.
- When serum 25(OH)D concentrations are below 27.7 nmol/L, each unit-nmol/L increase is associated with a 7% decrease in the risk of death from all causes.
They said, "Our study revealed that KSD patients with inadequate serum 25(OH)D levels were more likely to experience all-cause mortality. Hence, it is essential to maintain sufficient blood 25(OH)D levels and prevent 25(OH)D insufficiency in KSD patients to increase their lifespan."
Reference:
Gao, Meng, et al. "Association of Serum 25-hydroxyvitamin D Concentrations With All-cause Mortality Among Individuals With Kidney Stone Disease: the NHANES Database Prospective Cohort Study." Frontiers in Endocrinology, vol. 14, 2023, p. 1207943.
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.