Low Parathyroid Levels tied to Peritonitis in Incident peritoneal dialysis patients

Abnormalities in serum parathyroid hormone (PTH) are exceedingly common in end-stage renal disease (ESRD) patients, on maintenance dialysis and associated with cardiovascular disease, disturbances in bone mineral disorders, even increased morbidity and mortality in most epidemiologic studies. In a recent study, researchers have reported that the low levels of PTH are associated with the peritonitis among incident peritoneal dialysis (PD) patients. The study findings were published in the BMC Nephrology on January 29, 2021.
Peritoneal dialysis related peritonitis remains the major and life-threatening infection-related complication and is closely related to loss of catheter function, impairment of the peritoneal membrane, eventually discontinuation of peritoneal dialysis therapy, conversion to hemodialysis. Peritonitis results in an overall mortality rate of up to 15% of PD patients. Risk factors associated with peritonitis, including older age, diabetes, hypoalbuminemia, also reflect a status of malnutrition in PD patients. Therefore, researchers of the Guizhou Provincial People's Hospital, China, suspected that the low serum PTH levels may play a role in the incidence of PD-related peritonitis and conducted a study, to evaluate the association of serum PTH levels with PD-related peritonitis.
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