mCC/eGFR Ratio: A New Indicator of Muscle Mass and Mortality Risk in ICU Patients, Study Finds
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Netherlands: A recent study published in BMC Nephrology has shed light on the modified creatinine clearance/eGFR (mCC/eGFR) ratio as a potential indicator of musNetherlandscle mass in intensive care unit (ICU) patients, with significant implications for predicting mortality.
The findings showed that the mCC/eGFR ratio correlates with both in-hospital and long-term mortality, making it a readily accessible measure of muscle mass in ICU patients.
"In-hospital mortality rates were 27% for patients in the lowest mCC/eGFR quartile, compared to just 11% in the highest quartile. Five years after discharge, the mortality rate remained elevated at 37% for those in the lowest quartile, while it dropped to 19% for those in the highest," the researchers reported.
Muscle mass is a critical factor in the health of ICU patients, influencing their recovery trajectory and overall prognosis. Loss of muscle mass, or cachexia, is commonly observed in critically ill individuals, and it has been linked to poorer outcomes. While muscle mass can be assessed using 24-hour urinary creatinine excretion (UCE), its effectiveness for predicting risk in individual patients is hindered by the absence of age-, sex-, weight-, and length-specific reference values for UCE. The ratio of measured creatinine clearance (mCC) to estimated glomerular filtration rate (eGFR) may help address this limitation.
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