Metformin may be potential treatment of non-diabetic CKD, finds study
Metformin, widely used for treatment of type 2 diabetes, inhibits mitochondrial respiratory chain complex and transiently decreases mitochondrial energy production. This energetic stress increases intracellular AMP level, leading to AMP-activated protein kinase (AMPK) activation. AMPK is a metabolic sensor and has several beneficial effects on intracellular homeostasis, such as regulating glycolysis and lipid metabolism. As shown by various lines of evidence, AMPK activation is important for the beneficial effect of metformin on type 2 diabetes treatment.
In addition to diabetic-associated diseases, several studies have reported that metformin ameliorates tumor progression, inflammatory disease, and tissue fibrosis. Considering its relatively low cost and safety, metformin is useful not only for diabetes-related diseases but also for non-diabetic diseases.
In a recently published study report, researchers have highlighted that metformin significantly prolongs the survival of mice in a model that simulates the pathology of non-diabetic chronic kidney disease (ND-CKD) by ameliorating pathological conditions like reduced kidney function, glomerular damage, inflammation and fibrosis. The findings have been published in Scientific Reports.
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