Obesity-related indices associated with hyperuricemia among women
In a large Taiwanese study, researchers found that obesity-related indices were associated with hyperuricemia, and there were sex differences in these associations, with stronger associations observed in women compared to men. The lipid accumulation product (LAP), body mass index (BMI) and visceral adiposity index (VAI) were the strongest predictors of hyperuricemia among both men and women, according to this study.
Hyperuricemia is linked to developing diabetes, gout, kidney, and cardiovascular diseases. Previous research shows a link between hyperuricemia and the onset of diabetes, gout, kidney, and cardiovascular diseases. While obesity is a known risk factor for hyperuricemia, there is a lack of data on sex differences in this association. To address this gap, a team of researchers investigated the correlation between various obesity indices and hyperuricemia in Taiwan. The data were sourced from the Taiwan Biobank and included 122,067 participants.
The team enrolled 121,888 participants, including 43,790 men and 78098 women.
The critical considerations noted in the study are:
- The prevalence rates of hyperuricemia in men and women were 29.8% and 13.6%, respectively.
- Among both male and female participants, there was an association between high values of body shape index (ABSI), waist-to-height ratio (WHtR), waist–hip ratio (WHR), LAP, conicity index (CI), visceral adiposity index (VAI), body adiposity index (BAI), abdominal volume index (AVI), BMI, and body roundness index (BRI) and hyperuricemia.
- The interactions between sex and all ten indices were significant for hyperuricemia.
- In men, LAP had the highest area under the curve. BMI, VAI, AVI, BRI, WHtR, BAI, WHR, CI and ABSI followed this observation.
- In women, LAP also had the highest area under the curve, followed by BMI, VAI, WHtR, BRI, AVI, WHR, BAI, CI and ABSI.
In conclusion, obesity-related indices were associated with hyperuricemia in this large Taiwanese study, and sex differences were found in these associations, with stronger associations in women than in men.
The main strengths of this study include the comprehensive assessments and their associations with hyperuricemia in both men and women.
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