Osteoporotic fractures are less common in ESKD patients using phosphate binders: Study
A new study by the team of Ji Eun Kim found that osteoporotic fractures are less common in end-stage kidney disease (ESKD) patients who use phosphate binders. The findings of this study were published in the journal of Nephrology Dialysis and Transplantation.
The patients with end-stage renal disease more frequently face osteoporosis measured from dual-energy X-ray absorptiometry (DXA). This condition is linked to a high incidence of fractures and a high all-cause mortality. In addition to the usual complications of osteoporosis, the end-stage renal disease has an increased risk of osteoporotic fractures in association to mineral and bone disease (MBD). Thus, this study looked into the relationship between osteoporotic fracture in dialysis patients and oral phosphate binders, which are the standard for MBD therapy.
The National Health Insurance database provided data on incident dialysis patients lacking a history of osteoporotic fractures for this study. Based on their initial 1-year prescription profiles, these participants were divided into four groups as non-calcium-based phosphate binder (NCBPB), mixed (calcium and non-calcium-based binders), non-calcium-based phosphate binder (CBPB) and non-phosphate binder (non-user). The incidence of newly onset osteoporotic fractures following a year of dialysis was the main outcome. The secondary outcomes focused on the mortality and cardiovascular events.
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