Post-AKD kidney function may independently predict long-term prognosis of patients with AKI on dialysis: JAMA
Taiwan: A recent cohort study of 6703 participants has revealed the cruciality of evaluating baseline and post-acute kidney disease (AKD) kidney function for understanding the risk of adverse outcomes in patients with acute kidney injury requiring dialysis (AKI-D).
The researchers, in their study published in JAMA Network Open, revealed that baseline kidney function and post-AKD kidney function were significant independent factors linked with major adverse cardiac events (MACEs), all-cause mortality, readmission, and end-stage kidney disease (ESKD) in patients with AKI-D.
"Worse post-AKD kidney function was linked with a progressive rise in the risk of adverse outcomes; however, AKD severity was not associated with adverse outcomes," the researchers wrote.
The researchers mentioned significant associations of interplay among baseline kidney function, severity of acute kidney disease, and post-AKD kidney function with patient outcomes. However, a comprehensive understanding of how these factors are collectively associated with mortality, MACEs, and ESKD in patients with AKI-D is yet to be explored fully. Considering this, Heng-Chih Pan, Chang Gung University College of Medicine, Taoyuan, Taiwan, and colleagues aimed to examine the associations of baseline kidney function, AKD severity, and post-AKD kidney function with MACEs, mortality, and ESKD in patients with AKI-D.
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