Pregnancy in kidney transplant recipients tied to Postpartum Creatinine Elevation Without Long-Term Graft Impact: Study
Turkey: Researchers have found in a new study that pregnancy in kidney transplant recipients is associated with a rise in creatinine levels during the postpartum period; however, this does not significantly affect long-term graft survival.
The study, published in International Urology and Nephrology, systematically reviewed and analyzed existing evidence on the long-term effects of pregnancy in women who have received kidney transplants. Mehmet Kanbay, Department of Medicine, Division of Nephrology, Koc University School of Medicine, Istanbul, Turkey, and colleagues aimed to clarify uncertainties surrounding how pregnancy may influence graft function, patient survival, and other key clinical parameters such as serum creatinine, estimated glomerular filtration rate (eGFR), and proteinuria.
Pregnancy after kidney transplantation involves significant physiological shifts that may place stress on the transplanted kidney. While some earlier research had indicated minimal long-term effects, the inconsistency of findings warranted a detailed investigation. The comprehensive review and meta-analysis pooled data from 19 eligible studies out of more than 6,000 screened publications. All included studies compared outcomes in pregnant kidney transplant recipients with non-pregnant transplant recipients, focusing on adults over the age of 18.
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