Proton Pump Inhibitors May Speed Up Kidney Disease Progression in Pre-ESRD Patients: Study
Taiwan: A new nationwide population-based study has raised concerns about the potential impact of proton pump inhibitors (PPIs) on renal disease progression in patients with pre-end-stage renal disease (pre-ESRD). The study revealed that PPI use may accelerate the progression of chronic kidney disease (CKD) to kidney failure.
"Our study highlights the heightened renal risk, particularly for patients with moderate to advanced CKD, when prescribing PPIs, emphasizing the need for careful consideration by clinicians managing pre-ESRD patients with PPIs and H2 blockers (H2Bs)," the researchers wrote in BMC Nephrology.
Although proton pump inhibitors are widely prescribed for gastrointestinal (GI) diseases, numerous studies have raised concerns about their potential adverse effects on kidney health. Most existing evidence has focused on evaluating the risks associated with PPI use in individuals with normal renal function, with limited data on their impact in patients with moderate to advanced chronic kidney disease. Ching-Lan Cheng, National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan, and colleagues address this gap by examining the accelerated decline in renal function associated with PPI use and the heightened risk of acute kidney injury (AKI) in pre-end-stage renal disease patients.
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