Psoriasis patients may be at higher risk of developing chronic kidney disease
China: A recent study published in Nephrology has shown an association between genetically predicted psoriasis and a higher risk of chronic kidney disease (CKD). This association may be critical for clinicians to monitor kidney function and prescribe potentially nephrotoxic drugs during psoriasis management.
Psoriasis is a chronic inflammatory disease that has been associated with metabolic and cardiovascular comorbidities, specifically in young patients and patients with more severe forms of the disease. Recent studies have also linked psoriasis to kidney disease. However, studies assessing the association between psoriasis and the risk of CKD have reported conflicting results. Furthermore, no research has been done on the causal nature of the possible association.
Xianding Wang, Department of Urology/Institute of Urology, West China Hospital, Sichuan University, Chengdu, China, and colleagues aimed to explore the association between psoriasis and the risk of chronic kidney diseases by conducting a population-based cross-sectional study and Mendelian randomization analysis.
They used data from the National Health and Nutrition Examination Survey (NHANES). The potential association between psoriasis and CKD risk was estimated using Logistic regression analyses. Further, the causality was evaluated by performing a Mendelian randomization analysis using large-scale genome-wide association studies of psoriasis and CKD. Inverse variance-weighted (IVW) analysis was used as the primary method. 16 750 participants were included in the observational study.
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