Rituximab effective Steroid-Sparing Treatment of steroid-dependent or frequently relapsing nephrotic syndrome: BMC
A new study published in the journal of BMC Nephrology revealed rituximab to be an effective and safe steroid sparing medication in individuals with steroid dependent (SD)/frequent relapsing (FR) nephrotic syndrome (NS). Longer remission is attained when a follow-up maintenance dosage is administered following the initial course.
According to the Kidney Disease: Improving Global Outcome (KDIGO) guidelines, glucocorticoid medication is advised as the first-line treatment for adult MCD since it has a positive prognosis. Although 75–90% of patients get a full response, up to 25% of steroid responders experience frequent relapses (FR), and 30–40% acquire steroid dependence.
Although corticosteroids are very effective in treating minimal change disease, many individuals develop steroid dependence or relapse often. Primary Focal Segmental Glomerulosclerosis (FSGS) has a lower response rate. An efficient substitute is needed as extended exposure to corticosteroids should be avoided and in this context, Rituximab is an agent with promise. Omri Feder and colleagues conducted a review to assess long-term safety and effectiveness of Rituximab therapy in adult patients with SD/FR NS.
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