Serum Albumin levels can predict prognosis of patients with CKD

The key findings of this study were:

1. The included patients were 522 (69.23%) men with a mean age of (66.86 13.41) years. The average baseline ALB and eGFR were 3.89 0.59 and 33.43 17.97 ml/min/1.73 m2, respectively.

2. The eGFR decreased by 2.65 mL/min/1.73 m2/year on a yearly basis.

3. With a median follow-up of 36.0 months, 218 people (28.9%) were diagnosed with renal prognosis.

4. After adjusting for variables, the baseline ALB showed an inverse relationship with renal prognosis and renal function deterioration.

5. The relationship between the renal prognosis and ALB was nonlinear, with the inflection point of ALB occurring at 4.3 g/dL.

6. The effect sizes (HR) on the left and right sides of the inflection point were 0.42 (0.32, 0.56) and 6.11 (0.98, 38.22), respectively.

ALB decline was closely correlated with poor renal prognosis and renal function decline when ALB was lower than 4.1 g/dL. From a therapeutic perspective, postponing the course of CKD makes sense by slowing the drop in ALB.

Reference:

Cheng, T., Wang, X., Han, Y., Hao, J., Hu, H., & Hao, L. (2023). The level of serum albumin is associated with renal prognosis and renal function decline in patients with chronic kidney disease. In BMC Nephrology (Vol. 24, Issue 1). Springer Science and Business Media LLC. https://doi.org/10.1186/s12882-023-03110-8