Severe vitamin D deficiency increases risk of mortality in AKI patients: Study

A total of 259 adult AKI patients who were hospitalized to the intensive care unit (ICU) at Henan University of Chinese Medicine's Fifth Clinical Medical College (Zhengzhou People's Hospital) between July 2021 and June 2023 were retrospectively recruited for this study. They were divided into four groups according to their 25-hydroxyvitamin D (25-OHD) levels as severe deficiency (less than 10 ng/mL), deficiency (10–20 ng/mL), insufficiency (20–30 ng/mL), and sufficiency (more than 30 ng/mL). After adjusting for possible confounders, the effect of vitamin D concentrations on the 90-day all-cause mortality risk was examined using multivariate survival analysis utilizing Cox regression model.

The people with severe deficiency had the highest 90-day all-cause death rate (50.8%), followed by people with deficiency (35.0%), insufficiency (23.9%), and sufficiency (12.2%). While deficiency and insufficiency were not substantially linked to the risk of 90-day all-cause mortality, severe deficiency was independently linked to a greater risk of 90-day all-cause death when compared to sufficiency, according to multivariate Cox regression. Overall, severe vitamin D insufficiency (<10 ng/mL) considerably increases the risk of death in AKI patients, this highlights` the necessity for monitoring and perhaps augmenting vitamin D in this population.

Source:

Shen, B., Liu, B., Wang, Y., Wang, R., & Gu, D. (2024). Severe Vitamin D Deficiency is Associated with Mortality Risk in Critically Ill Patients with Acute Kidney Injury. In International Journal of General Medicine: Vol. Volume 17 (pp. 5153–5162). Informa UK Limited. https://doi.org/10.2147/ijgm.s477114