SGLT2 inhibitors lower chronic kidney disease risk in diabetes patients with higher DCSI: Study
Taiwan: The use of sodium-glucose cotransporter-2 inhibitors (SGLT2Is) significantly lowers the risk of chronic kidney disease (CKD) in type 2 diabetes patients with a higher DCSI (diabetes complications severity index), reveals a recent study published in the Journal of Nephrology.
Wei-Syun Hu from China Medical University in Taichung, Taiwan, and colleagues aimed to investigate the risk of CKD in type 2 diabetes patients with different scores of adapted DCSI who received SGLT2 inhibitors in a retrospective analysis. The DCSI quantifies the severity and presence of complications based on seven body systems or dimensions. It converts laboratory results and diagnostic codes into a 14-level metric quantifying the long-term diabetes effects on seven body systems.
The analysis included 113,449 patients with type 2 diabetes mellitus (T2DM) from the Taiwan NHIRD (National Health Insurance Research Database). They analyzed data collected from 107,440 patients demonstrating a change in DCSI score of < 1 per year, 2289 patients with a score change of > 2 per year, and 3720 patients with a change in score of 1 to 2 per year.
CKD risk throughout the follow-up period was assessed using Cox proportional hazard models. They were adjusted for age, sex, comorbidities, and medications of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, glucosidase inhibitors, dipeptidyl peptidase-4 inhibitors, biguanides, meglitinides, glucagon-like peptide-1 receptor agonists, insulin, a thiazolidinedione, and sulphonylurea.
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