Strict Phosphate Control Delays CAC Progression In Patients On Hemodialysis, EPISODE Trial
In patients on maintenance dialysis, cardiovascular mortality risk is remarkably high, which can be partly explained by severe coronary artery calcification (CAC). In a study, strict phosphate control shows promise for delaying CAC progression in patients on hemodialysis. The study findings were published in the Journal of the American Society of Nephrology on February 26, 2021.
Hyperphosphatemia has been reported to be associated with the severity of CAC. However, the optimal phosphate range in patients on dialysis remains unknown. Therefore, Yoshitaka Isaka and his team conducted a study to compare the effects on CAC progression of two types of noncalcium-based phosphate binders and of two different phosphate target ranges.
Evaluate the New Phosphate Iron-Based Binder Sucroferric Oxyhydroxide in Dialysis Patients to advance the Practice of EBM (EPISODE), was a randomized, open-label, multicenter, interventional trial with a two by two factorial design. The researchers included a total of 160 adults on dialysis and randomly assigned them to receive the sucroferric oxyhydroxide or lanthanum carbonate to reduce the serum phosphate to two target levels (3.5–4.5 mg/dl in the strict group and 5.0–6.0 mg/dl in the standard group). The major outcome assessed was a percentage change in CAC scores during the 12-month treatment.
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.