Beta-blockers improve outcomes after traumatic brain injury: Study
China: The administration of B-blockers are safe and effective for traumatic brain injury (TBI), finds a recent review in the Journal of Trauma and Acute Care Surgery. Therefore researchers suggest the use of B-blockers in TBI care.
TBI can trigger catecholamine surge and paroxysmal sympathetic hyperactivity (PSH), which can lead to poor outcome. Beta adrenergic receptor blockers (β-blockers) are potential therapeutic agents for the prevention of catecholamine surge and PSH, than can improve survival after TBI. The aim of the study by Liang Liu, Department of Neurosurgery, Affiliated Hospital of Southwest Medical University, Luzhou, China, and colleagues was to investigate the effect of β-blockers on outcomes in TBI patients.
For the purpose, the researchers searched the online databases from inception to September 25, 2020 for randomized controlled trials, nonrandomized controlled trials, and observational studies that reported the effect of β-blockers on several outcomes after TBI. The outcomes included mortality, functional measures, and cardiopulmonary adverse effects of β-blockers (e.g. hypotension, bradycardia and bronchospasm).
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