Cilostazol may prevent recurrent stroke without bleeding risk, finds study
UK: The use of cilostazol may reduce the risk of recurrent stroke without increasing hemorrhage risk, suggests a recent study published in the journal Stroke.
Cilostazol is a phosphodiesterase 3' inhibitor that is used in Asia-Pacific countries for the prevention of stroke but is rarely used elsewhere. In addition to weak antiplatelet effects, it aids myelin repair and astrocyte-neuron energy transfer and stabilizes endothelium. These effects may be used for the prevention of small vessel disease progression.
Caroline McHutchison, University of Edinburgh, United Kingdom, and colleagues conducted a systematic review and meta-analysis of unconfounded randomized controlled trials of cilostazol to prevent stroke, cognitive decline, or radiological small vessel disease lesion progression. They calculated Peto odds ratios (ORs) and 95% CIs for recurrent ischemic, hemorrhagic stroke, death, adverse symptoms, with sensitivity analyses.
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