CPAP treatment lowers mortality in stroke and TIA in patients with sleep disorders: Study
A new study published in the Journal of Stroke and Cardiovascular Disease showed that continuous positive airway pressure (CPAP) has been linked to a lower all-cause death rate in patients with sleep disordered breathing who have had a stroke or a transient ischemic attack (TIA).
The incidence of stroke and transient ischemic attacks is independently associated with sleep-disordered breathing, particularly obstructive sleep apnea (OSA). Chronic systemic hypertension, endothelial dysfunction, hypercoagulability, cardiac arrhythmias, impaired glycemic control that results in diabetes, heart failure, coronary artery disease, and systemic inflammation with elevated levels of inflammatory markers (e.g., VEGR, CRP, IL-6, and TNFα) that lead to atherosclerosis are all possible long-term consequences of OSA.
About 70% of stroke patients have OSA, which is strongly associated with the risk of stroke. Because of the short follow-up period and small sample sizes of earlier studies, it is uncertain if therapy with continuous positive airway pressure lowers the risk of stroke recurrence or death in post-stroke patients. This study examined changes in stroke mortality and recurrence among post-stroke patients with sleep-disordered breathing receiving CPAP in an effort to fill this information gap.
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