Lower LDL-C associated with low risk of CKD progression, finds study

Published On 2021-10-22 04:30 GMT   |   Update On 2021-10-22 06:41 GMT

Korea: According to a recent study, there is a graded connection between LDL-C and the probability of poor cardiovascular outcomes in patients with chronic kidney disease (CKD). Low-density lipoprotein cholesterol (LDL-C) <70 mg/dL was associated with the lowest risk of CKD progression, indicating that a lower LDL-C goal may be appropriate.

The study indicates that lipid management is important in CKD patients without kidney replacement therapy.

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The findings were published in Nutrition, Metabolism & Cardiovascular Diseases on 12th October 2021.

The optimum amount of low-density lipoprotein cholesterol to avoid cardiovascular disease in people with chronic kidney disease is unclear. To clarify the same, Changhyun Lee, National Health Insurance Service Medical Center, Ilsan Hospital, Goyang-si, Gyeonggi-do, Korea, and colleagues aimed to investigate the relationship between LDL-C levels and poor cardiovascular and renal outcomes in Korean CKD patients, as well as to test the validity of the "lower, the better" statin consumption strategy. 

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The Korean cohort study for Outcome in Participants with CKD (KNOW-CKD) comprised a total of 1,886 patients. LDL-C levels in patients were divided into four categories: 70, 70–99, 100–129, and 130 mg/dL. The primary outcome was the number of significant cardiovascular events that lasted for a lengthy period of time (eMACEs). All-cause mortality and CKD progression were secondary outcomes.

Although CKD is associated with an increased risk of cardiovascular disease, the positive effects of lowering LDL-C targets in individuals with CKD remain unclear. LDL-C levels of 70 mg/dL were linked with a greater risk of poor cardiovascular outcome in individuals with CKD in this prospective cohort research. Patients with LDL-C levels less than 70 mg/dL had a reduced risk of CKD development.

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In conclusion, LDL-C level <70 mg/dL was associated with a higher risk of adverse cardiovascular outcome in patients with CKD. Risk of the progression of CKD was also lower in patients with LDL-C level <70 mg/dL.Thus, lipid management is important in CKD patients without kidney replacement therapy.

Reference:

Lee, C., Park, J. T., Chang, T.-I., Kang, E. W., Nam, K. H., Joo, Y. S., Sung, S.-A., Kim, Y. H., Chae, D.-W., Park, S. K., Ahn, C., Oh, K.-H., Yoo, T.-H., Kang, S.-W., & Han, S. H. (2021). Low-density lipoprotein cholesterol levels and adverse clinical outcomes in chronic kidney disease: results from the KNOW-CKD. In Nutrition, Metabolism and Cardiovascular Diseases. Elsevier BV. https://doi.org/10.1016/j.numecd.2021.09.037

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Article Source : Nutrition, Metabolism & Cardiovascular Diseases

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