Vitamin D, potential treatment for cerebral vasospasm? Study throws light
Frankfurt, Germany: The administration of vitamin D could be considered as an optional treatment for the prevention of cerebral vasospasm (CVS), suggests a recent study in the journal Neurosurgery. According to the study, 1,25-VitD3 attenuates CVS after subarachnoid hemorrhage (SAH) by inducing stroma-cell-derived factor (SDF) 1α.
Cerebral vasospasm is a feared complication of SAH resulting in secondary stroke. Current CVS-treatment strategies have failed to improve patient outcomes. Keeping in mind the complex pathophysiology that involves multiple pathways it is not unexpected that simple vasodilator or anti-inflammatory therapy fail to substantially impact on the CVS severity.
1,25-dihydroxycholecalciferol (1,25-VitD3) is known to improve vascular regeneration in response to local vascular-injury. Also, 1,25-VitD3 has anti-inflammatory effects and has been suggested to induce protective vascular genes. Against this background, Sepide Kashefiolasl, Goethe-University, Frankfurt, Germany, and colleagues explored the vitamin D system as a potential treatment for CVS.
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