ICMR-National Institute Of Malaria Research Gets CDSCO Panel Nod To Study Curcumin
New Delhi: In a significant development, the ICMR (Indian Council of Medical Research)- the National Institute of Malaria Research has got approval from the Subject Expert Committee (SEC) functional under the Central Drug Standard Control Organisation (CDSCO) to conduct the clinical trial of Curcumin (Biocurcumax).
However, this approval is subject to the condition that the firm should submit the outcome of most unexpected adverse events and methods for evaluation for parasitic clearance.
This came after the firm presented Phase IIa clinical trial protocol No. NIMR- Ipca/ARCU/PIIa-16.
Curcumin is a diarylheptanoid, belonging to the group of curcuminoids, which are phenolic pigments responsible for the yellow color of turmeric.
Research suggests that curcumin, a polyphenolic organic molecule derived from turmeric, inhibits chloroquine-resistant Plasmodium falciparum growth in culture in a dose-dependent manner with an IC(50) of approximately 5 microM. Additionally, oral administration of curcumin to mice infected with the malaria parasite (Plasmodium berghei) reduces blood parasitemia by 80-90% and enhances their survival significantly. Thus, curcumin may represent a novel treatment for malarial infection.
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