Sun Pharma-Moebius Medical announce dual publications on symptomatic knee osteoarthritis treatment MM-II in Osteoarthritis and Cartilage

The second publication, titled “Empty large liposomes reduce cartilage degeneration in osteoarthritic rats by forming a lubricative coating,” details MM-II’s unique mechanism of action. The research shows that MM-II forms a lubricative layer over cartilage surfaces, reducing friction and slowing cartilage degeneration. The authors suggest that the results of the clinical trial may be mediated through the coating of the cartilage surfaces, though additional mechanisms may contribute to the long term pain reduction seen in Phase 2b study.

“The data from these publications show that MM-II has the potential to provide durable pain relief for patients,” said Prof. Thomas J Schnitzer, MD, PhD, a rheumatologist and professor of Medicine at Northwestern University and lead author of the clinical trial manuscript. “With limited treatment options, lack of novel treatment approaches, and concerns around opioid use, MM-II may offer a promising alternative to hyaluronic acid and steroid treatments.”

Moshe Weinstein, CEO of Moebius Medical, added, “Having both our clinical data and our research on MM-II’s underlying mechanism of action published in the leading peer-reviewed journal for osteoarthritis further validates MM-II’s novel treatment approach.”

Coinciding with these publications, Sun Pharma and Moebius Medical are also presenting new data at the OARSI 2025 World Congress on Osteoarthritis taking place this week. Three abstracts were accepted for presentation at the congress, and the companies will also host a satellite symposium which exploring MM-II’s mechanism of action, clinical data and planned phase 3 program.